Adrenal Glands

The adrenal (from the latin, meaning “upon the kidneys”) glands sit on the superior tip of each kidney. Each adrenal gland weighs approximately 0.19 oucnes (7.5 grams). The glands are yellow in color and have a pyramid shape. Each adrenal gland has two sections that may almost be considered as separate glands. The inner portion ist he adrenal medulla (from the Latin marrow, meaning “inside”)> The outer portion, which surrounds the adrenal medulla, is the adrenal cortex (from the latin meaning “bark” because its appearance is similar to the outer covering of a tree). The adrenal cortex is the larger part of the adrenal glands, accounting for nearly 90percent of the gland by weight.

The adrenal cortex secrets more than two dozen different steroid hormones called the adrenocortical steroids, or simply corticosteroids. The adrenal cortex is divided into three major zones or regions each of which secrets a different type of corticosteroid. The outer region is the zona glomerulosa, which produces mineralocorticoids. The middle zone is the zona fasciculate, which accounts for the bulk of the cortical volume and produces glucocorticoids. The innermost, and smallest region, is the zona reticularis, which produces small quantities of the sex hormones.

Mineralocorticoids target the kidneys and increase reabsorption of sodium ions and water from the urine; stimulates loss of potassium ions through excretion of urine.

Glucocorticoids target most cells and release amino acids from skeletal muscles, lipids from adipoe tissues; promotes liver glycogen and glucose formation; promotes peripheral utilization of lipids; anti-inflammatory effects.

Androgens promote growth of pubic hair in boys and girls; in adult women, promotes muscle mass, bood cell formation and supports libido; in adult men, adrenal andgrogens are less significant because andorgens are released primarly from the gonads.

In mammals, the adrenal glands (also known as suprarenal glands) are endocrine glands that sit atop the kidneys; in humans, the right suprarenal gland is triangular shaped, while the left suprarenal gland is semilunar shaped. They are chiefly responsible for releasinghormones in response to stress through the synthesis of corticosteroids such as cortisol and catecholamines such as epinephrine. The adrenal glands affect kidney function through the secretion of aldosterone, a hormone involved in regulating the osmolarity of blood plasma.

Anatomically, the adrenal glands are located in the retroperitoneum situated atop the kidneys, one on each side. They are surrounded by an adipose capsule and renal fascia. In humans, the adrenal glands are found at the level of the 12th thoracic vertebra. Each adrenal gland has two distinct structures, the adrenal cortex and the medulla, both of which produce hormones. The cortex mainly produces cortisol,aldosterone and androgens, while the medulla chiefly produces epinephrine and norepinephrine. The combined weight of the adrenal glands in an adult human ranges from 7 to 10 grams.^[1]

[edit]Cortex

The adrenal cortex is devoted to the synthesis of corticosteroid hormones. Specific cortical cells produce particular hormones includingcortisol, corticosterone, androgens such as testosterone, and aldosterone. Under normal unstressed conditions, the human adrenal glands produce the equivalent of 35–40 mg of cortisone acetate per day.^[2] In contrast to the direct innervation of the medulla, the cortex is regulated by neuroendocrine hormones secreted by the pituitary gland and hypothalamus, as well as by the renin-angiotensin system.

The adrenal cortex comprises three zones, or layers. This anatomic zonation can be appreciated at the microscopic level, where each zone can be recognized and distinguished from one another based on structural and anatomic characteristics.^[3] The adrenal cortex exhibits functional zonation as well: by virtue of the characteristic enzymes present in each zone, the zones produce and secrete distinct hormones.^[3]

Zona glomerulosa (outer)

The outermost layer, the zona glomerulosa is the main site for production of mineralocorticoids, mainly aldosterone, which is largely responsible for the long-term regulation of blood pressure.

Zona fasciculata

Situated between the glomerulosa and reticularis, the zona fasciculata is responsible for producing glucocorticoids, chiefly cortisol in humans. The zona fasciculata secretes a basal level of cortisol but can also produce bursts of the hormone in response toadrenocorticotropic hormone (ACTH) from the anterior pituitary.

Zona reticularis

The inner most cortical layer, the zona reticularis produces androgens, mainly dehydroepiandrosterone (DHEA) and DHEA sulfate(DHEA-S) in humans.

[edit]Medulla

The adrenal medulla is the core of the adrenal gland, and is surrounded by the adrenal cortex. The chromaffin cells of the medulla, named for their characteristic brown staining with chromic acid salts, are the body's main source of the circulating catecholamines adrenaline(epinephrine) and noradrenaline (norepinephrine). Derived from the amino acid tyrosine, these water-soluble hormones are major hormones underlying the fight-or-flight response.

To carry out its part of this response, the adrenal medulla receives input from the sympathetic nervous system through preganglionic fibersoriginating in the thoracic spinal cord from T5–T11.^[4] Because it is innervated by preganglionic nerve fibers, the adrenal medulla can be considered as a specialized sympathetic ganglion.^[4] Unlike other sympathetic ganglia, however, the adrenal medulla lacks distinct synapses and releases its secretions directly into the blood.

Cortisol also promotes epinephrine synthesis in the medulla. Produced in the cortex, cortisol reaches the adrenal medulla and at high levels, the hormone can promote the upregulation ofphenylethanolamine N-methyltransferase (PNMT), thereby increasing epinephrine synthesis and secretion.^[3]

[edit]Blood supply

Although variations of the blood supply to the adrenal glands (and indeed the kidneys themselves) are common, there are usually three arteries that supply each adrenal gland:

§ The superior suprarenal artery is provided by the inferior phrenic artery

§ The middle suprarenal artery is provided by the abdominal aorta

§ The inferior suprarenal artery is provided by the renal artery

Venous drainage of the adrenal glands is achieved via the suprarenal veins:

§ The right suprarenal vein drains into the inferior vena cava

§ The left suprarenal vein drains into the left renal vein or the left inferior phrenic vein.

The suprarenal veins may form anastomoses with the inferior phrenic veins. Since the right supra-renal vein is short and drains directly into the inferior vena cava it is likely to injure the latter during removal of right adrenal for various reasons.

The adrenal glands and the thyroid gland are the organs that have the greatest blood supply per gram of tissue. Up to 60 arterioles may enter each adrenal gland.^[5] This may be one of the reasons lung cancer commonly metastasizes to the adrenals.

[edit]Terminology

The adrenal glands are named for their location relative to the kidneys. The term "adrenal" comes from ad- (Latin, "near") and renes (Latin, "kidney"). Similarly, "suprarenal" is derived from supra- (Latin, "above") and renes.

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